The Technology to Power Natural Healing

Nitric Oxide:

History & Science 


The History of Nitric Oxide

Nitric Oxide (NO) was first prepared in 1620 and first studied in 1720. It was poorly understood until the late 1900s. The discovery of the role of NO as fundamental to biologic function was so remarkable that hundreds of research papers led Nitric Oxide to be proclaimed "molecule of the year" in 1992 by the journal Science. Three NO researchers shared the 1998 Nobel Prize in Physiology or Medicine for their discovery that what had previously been known as EDRF (endothelium-derived relaxing factor) was, in fact, NO (13,14).

Evidence of its fundamental role in initiating and modulating a large number of physiological  processes began to emerge when scientists from distinct disciplines—immunology, cardiovascular physiology, and oncology—suddenly understood that they were studying the same molecule.

Nitric Oxide is highly reactive and diffuses freely across membranes but has a lifetime of only a few seconds. This combination of properties makes it an ideal signaling molecule both between adjacent cells and within a single cell.

Nitric Oxide: Scientific Rationale

As scientific knowledge about Nitric Oxide has grown along with a deeper understanding of its pervasive nature across so many pathways, there has been a significant focus on Nitric Oxide in the pharmaceutical industry, helping to create blockbuster drugs such as Viagra®. Delivery of Nitric Oxide and Nitric Oxide pathway modulators range from systemic oral administration and gaseous inhalation to topical application via donor carrier molecules and now, targeted therapy by plasma-generation technology, IonoJet™.


Nitric Oxide Enhances Blood Flow


Blood vessel regulation (1,9,10,11).

  • Blood vessel relaxation and dilation

  • Increased oxygen to tissues

  • Reduced factors that cause blood clots

  • Increased growth of new blood vessels


Nitric Oxide is a Potent Anti-Infective


Anti-microbial action (4-8)

  • Covalent binding to microbial DNA, proteins, and lipids

  • Activation of macrophage cytotoxicity

  • Pathogen impairment/killing

  • Active against multiple types of microorganisms


 Nitric Oxide Modulates the Immune System


Immune system modulation (1-4)

  • Regulation of immune cell activity and recruitment

  • Modulation of cytokine and chemokine expression


Nitric Oxide Encourages Tissue Regeneration


  Tissue regeneration (3,9)

  • Fibroblast migration and collagen deposition

  • Keratinocyte proliferation